Pediatric cardiomyopathy is a debilitating disease that leads to pump failure and sudden death; in fact, it is the leading cause of heart failure in children. Cardiomyopathy and heart failure in infants and children remain serious population health crises for children and their families and confer a great cost burden on society. In the United States, the estimated annual incidence of congenital cardiovascular malformations or cardiomyopathy in infants, children, and adolescents less than 19 years old is between 12,000 and 35,000.